Clinical research
Just as we push the boundaries of neuroscience in microgravity, Cortivision is dedicated to support revolutionizing clinical research. Our functional near infrared (fNIRS) system provides non-invasive, portable, and high-resolution physiological signals, offering clinicians real-time insights into cerebral hemodynamics where traditional imaging cannot reach.
Our Spectrum fNIRS offers continuous monitoring of changes in oxygenated and deoxygenated hemoglobin (HbO and HbR) and experimental regional cerebral oxygenation (rSO2). The sum of HbO and HbR (total hemoglobin – tHb) can be treated as a surrogate of changes in cerebral blood volume [Weerakkody et al., 2010, Slow vasogenic fluctuations of intracranial pressure and cerebral near infrared spectroscopy–an observational study, Acta neurochirurgica, 152(10), 1763–1769].
Multimodal Monitoring: Spectrum x ICM+
The power of real-time data integration to meet the rigorous demands of intensive care and surgical monitoring, our Spectrum device now seamlessly integrates with ICM+ (Intensive Care Monitor+, Cambridge Enterprise)– the world-leading clinical research software from the University of Cambridge.
Communication test window in ICM+ software
This integration allows for the simultaneous recording of fNIRS data (raw intensities, HbO, HbR) alongside other continuous physiological signals (ABP, ICP, EKG, CBFV, EtCO2 etc.). By combining high-resolution hemodynamic trends with the analytical power of ICM+, researchers can calculate advanced indices such as the hemoglobin volume index of dynamic autoregulation (HVx) to assess the state of cerebral autoregulation noninvasively in real-time. Read more: Bush et al., 2019, The role of near-infrared spectroscopy in cerebral autoregulation monitoring, Journal of neurosurgical anesthesiology, 31(3), 269–270.
Real time recording of fNIRS data using ICM+ (Signal Monitor view)
Review of Clinical fNIRS
Our commitment to clinical excellence is backed by extensive scientific evidence. We invite researchers to refer to the comprehensive review: Rahman et al., 2020, A Narrative Review on Clinical Applications of fNIRS, Journal of digital imaging, 33(5), 1167–1184.
This landmark publication explores the vast potential of fNIRS in neurology, psychiatry, and perioperative care, highlighting its role as a pivotal tool for monitoring brain health in conditions ranging from major depressive disorder to traumatic brain injury and surgical ischemia.
Example Ongoing Clinical Projects
Leading clinical institutes worldwide trust Cortivision devices for their critical research.
1. Measuring Cerebral Autoregulation (CA)
Researchers at the Kaunas University of Technology utilize Cortivision devices to pioneer new methods for measuring cerebral autoregulation during cardiac surgery. By analyzing the dynamic relationship between systemic blood pressure and cerebral hemodynamic, this project aims to reduce invasiveness and duration of CA measurement.
Dedicated headband for the clinical research
2. Focal Brain Ischemia During Cardiac Surgery
Wrocław University of Science and Technology x 4th Military Clinical Hospital in Wrocław
In collaboration with one of Poland’s clinical centers, our technology is used to monitor patients during complex cardiac surgeries assisted by cardiopulmonary bypass. The aim of the research is to answer the question if using fNIRS it is possible to detect early signs of focal cerebral ischemia localized in any brain lobe, enabling proactive neuroprotection during high-risk procedures.
3. Focal Cerebral Ischemia in Invasive Cardiology
Wrocław University of Science and Technology x Provincial Specialist Hospital in Wrocław
This study evaluates the diagnostic potential of fNIRS during invasive cardiology procedures, such as transcatheter aortic valve implantation or coronary angioplasty. By utilizing multi-channel and high-frequency sampling fNIRS, researchers aim to detect focal ischemia across multiple brain lobes and analyze arterial wave morphology—insights often missed by standard, low-frequency frontal oximeters. The project correlates hemodynamic signals with clinical data to assess cerebral autoregulation and identify early markers of post-operative cognitive deficits.
Partnership & Collaboration
Bringing Science to the Bedside Cortivision is more than a hardware provider; we are a partner in clinical discovery. We offer customized setups for ICU, operating room, and outpatient environments, ensuring our technology adapts to your specific clinical workflow.
Are you interested in integrating Spectrum into your clinical study? Contact Our Team
